Glycogen Storage Disorder: An Ayurvedic Anticipation

A developmental disorder of children is the most common clinical condition in the OPD and IPD of Vaidyaratnam PS Varier Ayurveda College, Kottakkal. One fine morning, an anxious couple arrived at the pediatric OPD with their five-year-old son, named Farhan, as he had not been able to walk independently until then. The boy also complained of bloating, recurrent respiratory infections, and recurrent diarrhea. Marked atony of the body muscles was also observed.

The case was not previously diagnosed, as it was his first approach for medical reassurance. At first glance, it appeared to be yet another case of developmental disorder; since it represents almost 1/3 of the patients hospitalized in this institution. As the patient was from a disadvantaged family, diagnostic investigations could not initially be recommended.

Then, a complete preliminary clinical examination was performed, which revealed enlarged liver. At this time, suspicion was raised as to whether an underlying metabolic cause predisposed to this liver enlargement. Therefore, it became inevitable to advise new investigations. Therefore, serum lactate and serum pyruvate were measured, however, they were found to be within normal physiological limits. Liver functions were analyzed showing elevated concentrations of SGPT and bilirubin, although this was not clinically discernible.

Fasting blood sugar was observed to be well below normal. These observations guided the diagnosis of the case to Glycogen storage disorder. Looking for the causes of this clinical condition, it was discovered that it was caused by a genetic predisposition or that it could be the result of a toxic accumulation in the body. Looking at the condition from an Ayurvedic point of view, it was understood to be the result of the accumulation of diseased metabolic toxins in the body. This in turn was precipitated by a decreased performance of digestive and metabolic activities in the body, both at the GIT level and at the tissue level. As established by Ayurvedic principles in such clinical conditions, the treatment was aimed at ensuring adequate mobilization of morbid metabolic toxins accumulated at the tissue level and improving the digestive and metabolic capacity of the involved GIT organs.

Simultaneously with the cleansing of accumulated toxins, the rejuvenation of the individual cells of the body was considered an equally important concern. Following these principles, the patient was subjected to a gentle massage with the prepared bolus of medicated powders immersed in warm sour and fermented porridge. Internally, Vilwadi tablets, Sudarsana tablets, Indukantham decoction and Dadimasthaka powder were prescribed. Along with Piper longum powder, known for its rejuvenating ability (in metabolic disorders of the liver and spleen), it was also recommended internally.

Gradually, to our greatest satisfaction, the diarrhea and bloating were markedly relieved and the boy seemed much happier. Meanwhile, a Liver Biopsy was performed, which confirmed the diagnosis previously made. Renal functions were monitored, however they were within normal ranges. Subsequently, the FBS was also significantly improved. Surprisingly, on day 45 of treatment, the patient that his parents brought to the OPD a few days before began to walk next to her.